MCHR1 (GPR24)
Melanin concentrating hormone receptor 1
MCHR1 (GPR24), also known as Melanin concentrating hormone receptor 1, is a class A G-protein-coupled receptor (GPCR). MCHR1 has received considerable attention, as potent and selective antagonists acting at that receptor display anxiolytic, antidepressant and/or anorectic properties. MCHR1 is the sole receptor expressed in rodents and couples to Gi and Gq proteins.
MCH is a ubiquitous vertebrate neuropeptide predominantly synthesized by neurons of the diencephalon that can act through two G protein-coupled receptors, called MCHR1 and MCHR2. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin.
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MCHR1 (GPR24) Related Products (45)
Related Products (45)
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MCH(human, mouse, rat)
0 ImagesSynonyms: Melanin-concentrating hormone(human, mouse, rat)MCH (human, mouse, rat) is a cyclic neuropeptide mainly synthesized by neurons in the lateral hypothalamic area. MCH (human, mouse, rat) also serves as an endogenous ligand for the melanin-concentrating hormone receptor (MHC receptor), with a binding IC50 of 0.3 nM and 1.5 nM for human MCH-1R and MCH-2R, respectively; its functional EC50 values are 3.9 nM and 88.7 nM. MCH (human, mouse, rat) acts not only as an orexigenic signal but also as a key integrating and regulatory hormone for energy homeostasis and sleep-wake cycles. MCH (human, mouse, rat) can be used in studies related to obesity, sleep disorders, and other associated conditions.
![[Ala17]-MCH](https://file.medchemexpress.com/product_pic/hy-p1204.gif "Click to View [Ala17]-MCH Product Detail")
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BMS-814580
0 ImagesCat. No.: HY-120608CAS No.: 1197420-11-3BMS-814580 is an orally active, highly efficacious MCHR1 inhibitor with a Ki of 16.9 nM against hMCHR1. BMS-814580 shows antiobesity activities.
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Neuropeptide EI, rat
0 ImagesCat. No.: HY-P1869CAS No.: 125934-45-4Neuropeptide EI, rat displays functional melanin concentrating hormone (MCH)-antagonist and melanocyte-stimulating hormone (MSH) agonist activity in different behavioral paradigms.
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ATC0065 free base
0 ImagesCat. No.: HY-107626ACAS No.: 509145-82-8
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MCHR1 antagonist 3
0 ImagesCat. No.: HY-136152CAS No.: 1069622-60-1MCHR1 antagonist 3 is a potent the melanin-concentrating hormone receptor-1 (MCHR1) antagonist. MCHR1 antagonist 3 is used to regulate energy metabolism.
![[Ala17]-MCH TFA](https://file.medchemexpress.com/product_pic/hy-p1204a.gif "Click to View [Ala17]-MCH TFA Product Detail")
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BI 186908
0 ImagesCat. No.: HY-120847CAS No.: 1453500-36-1BI 186908 is a selective and orally active MCH receptor 1 antagonist with an IC50 of 22 nM and a Ki of 14 nM. BI 186908 binds with comparably high affinity to the recombinant human, cynomolgus monkey (IC50 of 18 nM), dog (IC50 of 23 nM) and rat (IC50 of 18 nM) MCH-R1. BI 186908 can significantly reduce the body weight of diet-induced obese rats. BI 186908 can be used for the study of obesity.
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hMCH-1R antagonist 1
0 ImagesCat. No.: HY-P4745CAS No.: 353487-64-6hMCH-1R antagonist 1 (Compound 30) is an effective and selective antagonist of human melanin-concentrating hormone receptor 1 (hMCHR1) with an KB value of 3.6 nM. HMCH-1R antagonist 1 can bind to hMCHR1 and hMCHR2 with IC50 values of 65 nM and 49 nM, respectively. HMCH-1R antagonistist 1 can be used for metabolic research.
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SNAP 94847
0 ImagesCat. No.: HY-107625CAS No.: 487051-12-7SNAP 94847 is a novel, high affinity selective melanin-concentrating hormonereceptor1 (MCHR1) antagonist with (Ki= 2.2 nM, Kd=530 pM), it displays >80-fold and >500-fold selectivity over MCHα1A and MCHD2 receptors respectively. SNAP 94847 binds with high affinity to the mouse and rat MCHR1 with minimal cross-reactivity to other GPCR, ion channels, enzymes, and transporters.
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RGH-706
0 ImagesCat. No.: HY-181551CAS No.: 2027497-52-3RGH-706 is an orally active, blood-brain barrier-permeable, selective MCH1 receptor antagonist with an IC50 of 6.2 nM against hMCHR1. RGH-706 shows no antagonistic activity against hMCH2 receptors. RGH-706 improves obesity. RGH-706 can be used in research related to obesity and Prader-Willi syndrome.
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ATC0175 free base
0 ImagesCat. No.: HY-116031CAS No.: 509118-03-0ATC0175 (free base) is a potent and selective antagonist of melanin-concentrating hormone receptor 1 (MCH-R1) with an IC50 value of 3.4 nM, as well as good selectivity over the Y5 and the α2A receptors. ATC0175 (free base) is promising for research of obesity.
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BMS-830216
0 ImagesCat. No.: HY-12433ACAS No.: 1197420-06-6BMS-830216 is an antagonist of MCHR-1. BMS-830216 is a phosphate ester prodrug. BMS-830216 can be studied in obesity-related research.
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AMG-076 free base
0 ImagesCat. No.: HY-101699CAS No.: 693823-79-9AMG-076 free base is an orally bioavailable and selective MCHR1 antagonist. AMG-076 free base results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice.
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Ethyl linolenate-d5
0 ImagesEthyl linolenate-d5 is the deuterium labeled Ethyl linolenate. Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC50 of 70 μM. Anti-melanogenesis Effects.
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AMG-076
0 ImagesCat. No.: HY-101699ACAS No.: 1001438-96-5AMG-076 is an orally bioavailable and selective MCHR1 antagonist. AMG-076 results in significant reduction in body weight gain in nonobese mice fed a high-fat diet and in high-fat diet-induced obese (DIO) mice.
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ATC0175 (Standard)
0 ImagesCat. No.: HY-107624RCAS No.: 510733-97-8ATC0175 (Standard) is the analytical standard of ATC0175 (HY-107624). This product is intended for research and analytical applications. ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC50s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders.
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ADS103317
0 ImagesCat. No.: HY-111072CAS No.: 934474-97-2ADS103317 is an analog of Afatinib (HY-10261). ADS103317 weakly inhibits MCH-1R. Afatinib is an EGFR inhibitor. ADS103317 can be used in research related to non-small cell lung cancer.
